Neurofibroma

A moderately firm, benign, encapsulated tumor resulting from proliferation of SCHWANN CELLS and FIBROBLASTS that includes portions of nerve fibers. The tumors usually develop along peripheral or cranial nerves and are a central feature of NEUROFIBROMATOSIS 1, where they may occur intracranially or involve spinal roots. Pathologic features include fusiform enlargement of the involved nerve. Microscopic examination reveals a disorganized and loose cellular pattern with elongated nuclei intermixed with fibrous strands. (From Adams et al., Principles of Neurology, 6th ed, p1016)

Also Known As:

Neurofibromas

Neoplasms: 1324753
- Neoplasms by Histologic Type: 2
  - Nerve Tissue Neoplasms: 1
    - Nerve Sheath Neoplasms: 273
      - Neurofibroma: 844
Nervous System Diseases: 14178
- Neuromuscular Diseases: 2005
  - Peripheral Nervous System Diseases: 11383
    - Peripheral Nervous System Neoplasms: 48
      - Nerve Sheath Neoplasms: 273
        Neurofibroma: 844
- Nervous System Neoplasms: 235
  - Peripheral Nervous System Neoplasms: 48
    - Nerve Sheath Neoplasms: 273
      - Neurofibroma: 844

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